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Effect of cytochalasin B on epidermal cell migration in vitro *
Author(s) -
NISHIKAWA T.,
MARKS R.
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb15452.x
Subject(s) - medicine , dermatology , library science , square (algebra) , family medicine , gerontology , history , classics , computer science , geometry , mathematics
Summary Epidermal cell migration occurs at the edges of human skin fragments when these are placed in a suitable medium containing serum. In this investigation, in which seventy‐four skin explants were used, it was found that cytochalasin B reversibly inhibited this migratory process. Inhibition was observed at concentrations of greater than 2μg/ml, and only in a small proportion of explants cultured in the presence of cytochalasin at a concentration of Iμg/ml. The reversible inhibition of cell movement by cytochalasin B has been thought due to the disruption of cytoplasmic microfilaments and it is possible that this is the mode of action of this substance on the epidermis as well.