Premium
Ontogeny of pemphigus and bullous pemphigoid antigens in human skin
Author(s) -
MULLER H.K.,
KALNINS RENATE,
SUTHERLAND R.C.
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb15447.x
Subject(s) - bullous pemphigoid , pemphigus , antigen , pemphigoid , basement membrane , medicine , pemphigus vulgaris , pathology , immunology , dermatology , antibody
SUMMARY The development of pemphigus and bullous pemphigoid antigens in twenty‐nine human foetuses aged 9–40 weeks has been examined by immunofiuorescence. Pemphigus antigen was weakly demonstrable in the epidermal intercellular area at 9 weeks and strongly after 12 weeks, Bullous pemphigoid antigen was weak and patchy at 12 weeks and only consistently demonstrable with bright linear immunofiuorescence of the basement membrane zone after 23 weeks. Morphologically detectable epidermal basement membrane is already present by 9 weeks gestation.