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The invasion of burned skin by Pseudomonas aeruginosa
Author(s) -
CARNEY SHIRLEY A.,
DYSTER R. E.,
JONES R. J.
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb08016.x
Subject(s) - pseudomonas aeruginosa , virulence , microbiology and biotechnology , strain (injury) , penetration (warfare) , biology , hydrolysis , pseudomonadaceae , in vitro , bacteria , chemistry , biochemistry , anatomy , gene , genetics , operations research , engineering
SUMMARY When standard skin burns of mice were infected with a virulent strain of Pseudomonas aeruginosa there was rapid and extensive penetration of the burn and underlying tissues by the organisms. Under similar experimental conditions an a virulent strain of Ps. aeruginosa remained localized at the surface of the burned skin. In vitro experiments showed that heating did not make the proteins of skin more susceptible to hydrolysis by enzymes, since heated and unheated skin were hydrolysed to approximately the same extent by proteinases from both virulent and avirulent strains of Ps. aeruginosa.