Premium
Skin lesions in tyrosinosis: response to dietary treatment
Author(s) -
ZALESKI WITOLD A.,
HILL ALAN,
KUSHNIRUK WILLIAM
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb07562.x
Subject(s) - tyrosine , medicine , abnormality , hyperkeratosis , concomitant , skin lesion , phenylalanine , physiology , dermatology , biology , biochemistry , amino acid , psychiatry
SUMMARY A chronic form of tyrosinosis was diagnosed in a mentally retarded girl, aged 13. Concomitant findings were skin lesions of localized epidermolytic hyperkeratosis existing without remission from infancy. A diet low in phenylalanine and tyrosine was started to reduce the patient's blood tyrosine to a normal level. After 6 months of successful dietary control of blood tyrosine, an unexpected result was a complete remission of the skin lesions. The diet was abandoned after a total period of 14 months and the abnormality of tyrosine metabolism became immediately prominent again. Some 4 months later, the skin lesions have recurred. A possible relationship between the congenital skin disorder and the abnormal tyrosine metabolism in this case is considered.