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Studies on a patient with leucocytoclastic vasculitis ‘pyoderma gangrenosum’ and paraproteinaemia
Author(s) -
THOMPSON DOROTHY M.,
MAIN ROBERT A.,
BECK J. SWANSON,
ALBERTRECHT FRANK
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb07516.x
Subject(s) - pyoderma gangrenosum , medicine , dapsone , lesion , vasculitis , pathology , dermatology , disease
SUMMARY A patient with leucocytoclastic vasculitis, pyoderma gangrenosum, chronic pyelonephritis and a paraprotein of IgA type is described. The vasculitis responded favourably to dapsone therapy, while the pyoderma gangrenosum improved only when steroids were also given. During an exacerbation following withdrawal of dapsone, the serum IgG level fell early, but the β 1c globulin level remained normal. Immunofluorescence studies on a vasculitic lesion showed granular deposits of IgG and β 1c the walls of the blood vessels and a more extensive exudate of fibrin. Skin testing with bacterial antigens and patch testing to potassium iodide produced lesions which clinically, histologically and immunologically resembled the spontaneous vasculitic lesion.