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Effects of long wave ultraviolet radiation on photosensitizing and related compounds. I
Author(s) -
ALANI MILHIM D.
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb02990.x
Subject(s) - phototoxicity , fluorescence , hairless , acridine , psoralen , chemistry , photochemistry , irradiation , ultraviolet radiation , ultraviolet , radiochemistry , organic chemistry , biochemistry , materials science , optics , optoelectronics , physics , dna , nuclear physics , in vitro
SUMMARY The effects of long ultraviolet radiation (UVA) on the fluorescence of twenty‐four photosensitizing and related compounds were studied. Each compound was applied in two areas on the skin of hairless mice. One area was irradiated. The fluorescence in both areas was then inspected every day until it disappeared. Persistence and change of colour of the fluorescence as a direct immediate effect of UVA radiation on compounds having photoallergic potential, i.e. salicylanilide, halogenated salicylanilide and phenothiazine derivatives, was observed. Compounds known for their phototoxic effects, i.e. acridine dyes, did not show such changes after irradiation, while 8‐methoxypsoralen showed persistence of fluorescence without change of colour.