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Study of folate in psoriasis: blood levels, intestinal absorption and cutaneous loss
Author(s) -
TOURAINE R.,
REVUZ J.,
ZITTOUN J.,
JARRET J.,
TULLIEZ M.
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb02987.x
Subject(s) - malabsorption , psoriasis , folic acid , absorption (acoustics) , malabsorption syndromes , medicine , endocrinology , immunology , gastroenterology , physics , acoustics
SUMMARY Serum, red cell and squame folate content have been measured in fifty cases of psoriasis with extensive lesions. Reduced serum and red cell folate have been found in 44% of the patients. Folic acid absorption, studied in twenty‐six patients, was impaired in four and significantly increased in all the others. Squame folate content has been found too low to explain the folate deficiency. Malabsorption is a possible hypothesis but it occurs too rarely (four cases). The most likely explanation of folate deficiency seems to be an increased utilization of folate by the skin epidermal cells as a result of the rapid turnover rate. The increased absorption found in most cases investigated could be a compensatory mechanism to equilibrate folate balance.