Premium
A comparison of the effect of various topically active steroids on the clinical and histological features of psoriasis
Author(s) -
GOODWIN P.G.,
HAMILTON SUSAN,
FRY LIONEL
Publication year - 1973
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1973.tb01918.x
Subject(s) - psoriasis , medicine , dermatology , dermatologic agents , chemistry , biochemistry , antibiotics
SUMMARY The effect of betamethasone 17‐valerate, fluclorolone acetonide, fluocinolone acetonide and formocortal on the clinical and histological features and mitotic counts of psoriatic epidermis have been compared. In five of the six patients studied the preparations were used under polythene occlusive dressings. Biopsies were carried out before treatment and then at varying intervals for a week. All the four steroid preparations appeared effectively to reverse the psoriatic lesion. Betamethasone 17‐valerate and fluocinolone acetonide were found to give similar and slightly superior results to fluclorolone acetonide and formocortal on the criteria used in this study. It would appear that at the present time more potent topical steroids would not be of any advantage in the treatment of psoriasis. Drugs with a more selective action on the psoriatic process and without the steroid effect on collagen are required.