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THE EFFECT OF CHRONIC SUN DAMAGE ON THE ACTIVITY OF METABOLIC ENZYMES OF THE EPIDERMIS OF HUMAN SKIN *
Author(s) -
CERIMELE D.,
YAMASAWA S.,
SERRI F.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16190.x
Subject(s) - epidermis (zoology) , dehydrogenase , enzyme , biochemistry , lactate dehydrogenase , human skin , branched chain alpha keto acid dehydrogenase complex , pyruvate dehydrogenase phosphatase , lactic dehydrogenase , biology , malate dehydrogenase , chemistry , pyruvate dehydrogenase complex , anatomy , genetics
Summary.— The activity of 14 enzymes representative of the main metabolic pathways was assayed with microfluorometric techniques in the epidermis of exposed and unexposed skin of old men. The activity of 9 enzymes (α‐glycero‐phosphate dehydrogenase enolase, lactic dehydrogenase, isocitric and malic dehydrogenase, glucose‐6‐phosphate dehydrogenase, alanine and aspartate tranaminase. β‐hydroxylacyl dehydrogenase) was decreased in the exposed skin of old humans. The decrease of the activity of many enzymes in the exposed skin seems to be due to the accumulation of damage to epidermal cells.