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INCREASED IN VITRO RADIO‐SENSITIVITY OF MALGNANT MELANOMA INDUCED BY THE IN VIVO ADMINISTRATION OF CHLORPROMAZINE
Author(s) -
COOPER MICHAEL,
MISHIMA YUTAKA
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16101.x
Subject(s) - administration (probate law) , medicine , gerontology , library science , law , political science , computer science
Summary.— In vitro x‐ray irradiation with 3000 R of strips of Fortner's melanotic melanoma was found to have no effect on the rate of successful transplantation of these strips in hamsters. However, when the hamsters bearing; the melanomata from which the strips were obtained had been treated with 3·5 mg chlorpromazine before irradiation, the incidence of melanoma transplantability was reduced to 33%. Chlorpromazine‐treated melanomata which did grow after irradiation grew at a greatly reduced rate. It is postulated that chlorpromazine may increase the radio‐sensitivity of melanized cells by masking the free radical nature of melanin.