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THE GROWTH OF ADULT HUMAN SKIN IN VITRO
Author(s) -
LEVINE M.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16100.x
Subject(s) - dermis , epidermis (zoology) , in vitro , incubation , dna synthesis , organ culture , human skin , dna , biology , regeneration (biology) , andrology , chemistry , microbiology and biotechnology , biochemistry , anatomy , medicine , genetics
Summary.— In this report we investigate the role of serum in organ culture of adult human skin. The migratory overgrowth of dermis by epidermal cells is shown to depend on the presence of high molecular weight (mol. wt.) components of serum. Regeneration of the epidermis after 19 days' incubation occurs in the presence of 10% whole serum in the growth medium. DNA synthesis is found to increase in long‐term incubations in medium including serum components but not in the presence of Minimal Essential Medium (MEM) only.