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THE SELECTIVE DEPIGMENTING ACTION OF 8‐HYDROXYQUINOLINE ON HAIR GROWTH IN THE MOUSE
Author(s) -
SEARLE C. E.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16099.x
Subject(s) - depigmentation , hair growth , cabello , hair loss , dermatology , biology , medicine , chemistry , physiology , scalp
Summary.— Topical applications of 8‐hydroxyquinoiine to mouse skin cause depigmented hair to grow in patterns which change with time and appear to be closely associated with the hair growth cycles. Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single applications cause isolated bands of depigmented hair. Female mice are more sensitive than males, but some treated newborn mice were unaffected, 8‐Hydroxyquinaldine has a similar action. Compounds not showing this effect include 2 recognized depigmenting agents, some compounds related to 8‐hydroxyquinoline and some other analytical reagents for copper.