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ADENOSINE 3′ 5′‐CYCLIC MONOPHOSPHATE PHOSPHODIESTERASE IN SKIN
Author(s) -
HOLLA S. W. J.,
HOLLMAN E. P. M. J.,
MIER P. D.,
STAAK W. J. B. M.,
URSELMANN E.,
WARNDORFF J. A.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16077.x
Subject(s) - atopic dermatitis , phosphodiesterase , medicine , skin biopsy , substrate (aquarium) , adenosine , dermatology , cyclic adenosine monophosphate , significant difference , biopsy , enzyme , chemistry , endocrinology , biochemistry , biology , receptor , ecology
Summary.— The activity of cAMP phosphodiesterase under conditions of substrate saturation (V max ) and its substrate affinity (K m ) were measured in biopsy specimens from the lesions of atopic dermatitis, from atopic uninvolved skin, and from the skin of healthy controls. No significant difference was found between the atopic and the control specimens.