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THE ACTIVITY OF METABOLIC ENZYMES OF HUMAN EPIDERMIS IN RELATION TO AGE
Author(s) -
YAMASAWA S.,
CERIMELE D.,
SERRI F.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16075.x
Subject(s) - epidermis (zoology) , psoriasis , enzyme , human skin , pathological , enzyme assay , biology , physiology , metabolic activity , endocrinology , medicine , pathology , biochemistry , anatomy , immunology , genetics
Summary.— The activity of 14 enzymes, representative of the main metabolic pathways, was studied in the epidermis of 63 normal human subjects ranging in age from 1 month to 90 years. The activity was assayed with microfluorometric methods which allow the use of samples of epidermis very much reduced in size (0·3 μg to 1 μg). No difference of activity was observed in any of the enzymes studied despite the varied ages. The lack of influence of age on the activity of the enzymes in human epidermis enhances the significance of the variations which are reported in some pathological conditions (like psoriasis, chronic sun‐damaged skin and neoplasms).