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DEMONSTRATION OF INTERCELLULAR IMMUNOFLUORESCENCE AND EPIDERMAL HYSTERESIS IN BULLOUS FIXED DRUG ERUPTION DUE TO PHENOLPHTHALEIN
Author(s) -
SHELLEY WALTER B.,
SCHLAPPNER OTTO L. A.,
HEISS HAROLD B.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb16073.x
Subject(s) - phenolphthalein , drug eruption , erythema multiforme , immunofluorescence , erythema , dermatology , pemphigus , medicine , epidermis (zoology) , sensitization , pathology , drug , chemistry , antibody , immunology , anatomy , pharmacology
Summary.— We have reported a case of severe bullous erythema multiforme type of fixed drug eruption in which (1) multiple drugs were erroneously first indicated as the cause; (2) a false positive bullous patch test was obtained and discovered to be an intracorneal artefact, reflecting a new phenomenon, epidermal hysteresis; (3) a relationship to auto‐sensitization and pemphigus was discerned by the demonstration of direct intercellular immunofluorescence in the lower epidermis of the affected fixed sites only; (4) phenolphthalein was finally proven to be the specific cause by double‐blind oral challenge.