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STUDIES OF STAPHYLOCOCCAL TOXINS IN RELATION TO TOXIC EPIDERMAL NECROLYSIS (THE SCALDED SKIN SYNDROME)
Author(s) -
ARBUTHNOTT J. P.,
KENT JANET,
LYELL A.,
GEMMELL C. G.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb15412.x
Subject(s) - toxic epidermal necrolysis , staphylococcal scalded skin syndrome , toxin , staphylococcus aureus , dermatology , microbiology and biotechnology , medicine , hyaluronidase , chemistry , immunology , biology , bacteria , genetics , biochemistry , enzyme
Summary.— A diffusible product which causes extensive epidermal splitting in new‐born mice, has been obtained from phage group II staphylococci in a highly purified form. It is free of staphylococcal α‐toxin, δ‐toxin and hyaluronidase and has a molecular weight of approximately 33,000. Criteria of purity are presented and the possible role of this factor in experimental T.E.N. is discussed.