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PERCUTANEOUS ABSORPTION AND DISTRIBUTION OF 2‐NAPHTHOL IN MAN
Author(s) -
HEMELS H. G. W. M.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb07452.x
Subject(s) - conjugated system , urine , 1 naphthol , 2 naphthol , detection limit , absorption (acoustics) , chromatography , excretion , chemistry , plasma concentration , medicine , gastroenterology , organic chemistry , materials science , composite material , polymer
Summary.— A procedure is described for determining unchanged and conjugated 2‐naphthol in plasma and urine. The method, based on gas chromatography is rapid and has a limit of detection of approximately 2 g/m/1 −1 . Twenty‐four hours urine excretion data of 2‐naphthol, after therapeutic application of a 2‐naphthol‐containing ointment on the skin of patients, are reported. Plasma levels of 2‐naphthol and conjugated 2‐naphthol during and after topical treatment with a 2‐naphthol peeling paste were measured in 4 patients. Plasma levels of 2‐naphthol were significantly lower than the plasma levels of conjugated 2‐naphthol. The cutaneous barriers were found to be easily traversed by 2‐naphthol. The relevance of the data for clinical practice is discussed.