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NICKEL ANTIBODIES *
Author(s) -
FORMAN LOUIS,
ALEXANDER SUZANNE
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb07417.x
Subject(s) - library science , medicine , classics , history , family medicine , art history , computer science
Summary.— Eighteen patients with nickel sensitivity and 12 control patients were examined. Lymphocytes from these patients were cultured together with nickel sulphate (antigen). Evidence of cellular hypersensitivity was obtained by the following procedures: (1) Estimation of the percentage of lymphocytes transformed to lymphoblasts; (2) the uptake of C 14 thymidine in the lymphocyte cultures as evidence of DNA synthesis in the “challenged” cells; (3) the macrophage migration inhibition test, using the supernatant fluid from the cultures and guinea‐pig macrophages.