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THE EFFECT OF CLINDAMYCIN IN ACNE‐A CLINICAL AND LABORATORY INVESTIGATION
Author(s) -
CUNLIFFE W. J.,
C'OTTERILL J. A.,
WILLIAMSON B.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05095.x
Subject(s) - acne , clindamycin , excretion , medicine , dermatology , pathogenesis , chemistry , antibiotics , biochemistry
Summary.— Skin surface lipid composition and sebum excretion rate were determined before and after one and 2 months of therapy in patients taking clindamycin for severe acne vulgaris. All patients showed marked clinical improvement. Clindamycin produced a significant reduction in skin surface free fatty acids and a significant reciprocal increase in skin surface triglycerides after one and 2 months of therapy. There was no significant change in the sebum excretion rate. These results support the hypothesis that free fatty acids are important in the pathogenesis of acne vulgaris.