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THE EFFECT OF GLYCEROL ON THE PERCUTANEOUS ABSORPTION OF METHYL NICOTINATE
Author(s) -
HADGRAFT JONATHAN,
HADGRAFT J. W.,
SARKANY I.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05094.x
Subject(s) - glycerol , aqueous solution , chemistry , absorption (acoustics) , chromatography , erythema , organic chemistry , materials science , medicine , surgery , composite material
Summary.— The effect of glycerol on the rate of percutaneous absorption of methyl nicotinate from aqueous vehicles was investigated. The partition coefficients of methyl nicotinate between isopropyl myristate and aqueous solutions of glycerol were determined. The diffusivity of methyl nicotinate in various aqueous solutions of glycerol was also studied. It was shown that addition of glycerol in concentrations above 60% delayed the onset of erythema in human skin. The results suggest that this effect is related to the partition coefficient and diffusivity of methyl nicotinate in the aqueous vehicle. The osmotic effects of glycerol are negligible.