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COMBINED SURGICAL AND CHEMOTHERAPEUTIC TREATMENT OF FORTNER'S AMELANOTIC HAMSTER MELANOMA AMEL 3
Author(s) -
HANEKE E.,
WOHLRAB W.,
PEKER J.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05092.x
Subject(s) - medicine , hamster , melanoma , chemotherapy , mesocricetus , chemotherapeutic drugs , surgery , cancer research
Summary.— Golden hamsters were injected subcutaneously with melanoma cells and treated with vincaleucoblastine (VLB) after growth of the tumour. The prolongation of survival time after surgical removal of the tumour was compared with that of a non‐operated, VLB‐treated control group. The survival time of the operated hamsters was significantly prolonged. Although they did not show signs of tumour recurrence, 3 operated animals died from the VLB treatment. Comparing the results of both chemotherapy and combined chemotherapeutic and surgical treatment with those of experiments without cytostatic therapy, the markedly unfavourable effect of VLB on hamsters with melanomata is apparent. We suppose the immunosuppressive side‐effect of VLB to be responsible for this negative result.