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FLUORIMETRIC ASSAY OF CARBOXYLIC ESTER HYDROLASES IN GUINEA‐PIG SKIN AND THE EFFECTS OF PROPRANOLOL
Author(s) -
COTTON D. W. K.,
HURK JOSÉ J. M. A.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05076.x
Subject(s) - propranolol , guinea pig , chemistry , chromatography , carboxylic acid , pharmacology , medicine , biochemistry , endocrinology
Summary.— The application of a continuous fluorimetric assay technique to carboxylic ester hydrolases (including the cholinesterases) in skin is described. The kinetic properties of guinea‐pig skin preparations from different anatomical sites are reported. The in vitro and in vivo effects of propranolol and some other pharmacological compounds on carboxylic ester hydrolases from guinea‐pig skin are described. The results are discussed in relation to atopy.