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ALLERGIC CONTACT DERMATITIS FROM PYRETHRUM (CHRYSANTHEMUM SPP.)
Author(s) -
MITCHELL JOHN C.,
DUPUIS GILLES,
TOWERS G. H. NEIL
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05071.x
Subject(s) - pyrethrum , allergic contact dermatitis , chemistry , botany , traditional medicine , biology , allergy , toxicology , medicine , pesticide , agronomy , immunology
Summary.— In a patient with allergic contact dermatitis from pyrethrum ( Chrysanthemum spp., family Compositae), pyrethrosin produced strong, and pyrethrin II weak, positive patch test responses. Some other compounds derived from pyrethrum, viz. chrysanthemumic acid, the ethyl ester of this acid and its naturally occurring insecticidal esters, pyrethrin I, cinerin I and II, jasmolin I and II, and the synthetic ester allethrin and chrysanthemin, taraxasterol (pyrethrol) and tiglic acid produced negative patch test responses. In this patient, pyrethrosin, a sesquiterpene lactone which does not have insecticidal properties, was the principal allergenic fraction of pyrethrum derived from species of Chrysanthemum . Of the 8 esters of chrysanthemumic acid which were tested, pyrethrin II was also allergenic in this case.