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VARIATIONS IN SKIN SURFACE LIPID COMPOSITION AND SEBUM EXCRETION RATE WITH DIFFERENT SAMPLING TECHNIQUES II
Author(s) -
COTTERILL J. A.,
CUNLIFFE W. J.,
WILLIAMSON B.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb05048.x
Subject(s) - stratum corneum , excretion , acne , chemistry , composition (language) , forehead , stripping (fiber) , medicine , dermatology , biochemistry , surgery , pathology , materials science , composite material , linguistics , philosophy
Summary.— The technique of Sellotape stripping was used to investigate the role of the stratum corneum in modifying sebum excretion rate and skin surface lipid composition. All experiments were performed on the forehead. The stratum corneum influences the rate of sebum excretion as Sellotape stripping produced a significant increase in sebum excretion rate, but this effect was abolished by systemic antibiotics. Skin surface lipid composition, when sampled by absorbent papers, was not influenced by Sellotape stripping, but when sampled by an ether‐soaked sponge after Sellotape stripping, had a lessened epidermal lipid contribution. Thus the stratum corneum modifies skin surface lipid composition when sampled by an organic solvent. Absorbent papers may be preferable to other sampling techniques on the forehead in the investigation of the role of sebaceous biochemical factors in the pathogenesis of acne vulgaris.