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DEMONSTRATION OF BASAL CELL IMMUNOFLUORKSCENCE IN DRUG‐INDUCED TOXIC EPIDERMAL NECROLYSIS
Author(s) -
STEIN KENNETH M.,
SCHLAPPNER OTTO L. A.,
HEATON CHARLES L.,
DKCHERD JAMES W.
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb02224.x
Subject(s) - toxic epidermal necrolysis , epidermis (zoology) , drug , basal (medicine) , intracellular , penicillin , complement fixation test , antibody , biology , chemistry , pathology , immunology , microbiology and biotechnology , dermatology , antibiotics , medicine , pharmacology , biochemistry , anatomy , endocrinology , serology , insulin
Summary.— In 2 patients with toxic epidermal necrolysls due to penicillin and chlorpromazlne respectively, direct immunofluorescent studies revealed intercellular fixation of immunoglobulins and complement globulins confined to the basal cell Kiyer of the epidermis. These findings suggest that the drug binds to intercellular epidermal protein and that the basal cells are the target site of cellular damage in drug‐induced epidermal necrolysls.