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EFFECT OF RETINOIC ACID IN PSORIASIS, II
Author(s) -
MACDONALD ANGUS,
McMINN R. M. H.,
FRY LIONEL
Publication year - 1972
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1972.tb00315.x
Subject(s) - retinoic acid , psoriasis , placebo , medicine , dermatology , tretinoin , gastroenterology , physiology , pathology , chemistry , biochemistry , alternative medicine , gene
Summary.— Clinical and histological features and mitotic counts have been studied in the lesions of 11 patients with psoriasis who were treated with topically applied retinoic acid ointment for a period of 3 months. Serial biopsies were taken at monthly intervals from treated lesions in all 11 patients and from lesions treated with the unmedicated ointment base in 9. There was no significant difference between treated and placebo groups regarding any of the parameters studied. Irritant effects of the retinoic acid were prominent in 7 patients. The significance of these results is discussed in the light of the known mechanism of action of retinoic acid.