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HISTAMINE EXCRETION AND DERMOGRAPHISM IN URTICARIA PIGMENTOSA BEFORE AND AFTER ADMINISTRATION OF A SPECIFIC HISTIDINE‐DECARBOXYLASE INHIBITOR
Author(s) -
GREAVES MALCOLM W.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb14055.x
Subject(s) - histamine , histidine decarboxylase , excretion , urticaria pigmentosa , medicine , histidine , endocrinology , pharmacology , gastroenterology , dermatology , chemistry , biochemistry , enzyme
Summary.— The 24 h urinary histamine excretion was studied in 2 patients with severe urticaria pigmentosa before and after treatment with a specific histidine decarboxylase inhibitor, 4‐bromo‐3‐hydroxy‐benzyloxyamine‐dihy‐drogen phosphate (Brocresine). Urinary histamine excretion was greatly raised in both patients before treatment and there was no fall in excretion after treatment in either patient. There was no diminution in dermographism, measured by a quantitative technique, and no symptomatic improvement. These results do not support the view that Brocresine is an effective inhibitor of histidine decarboxylase in man.