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THE IN VITRO PENETRATION OF FLUOCINONIDE THROUGH HUMAN SKIN FROM DIFFERENT VOLUMES OF DMSO
Author(s) -
COLDMAN M. F.,
KALINOVSKY TANIA,
POULSEN B. J.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb14053.x
Subject(s) - penetration (warfare) , in vitro , human skin , penetration rate , chemistry , chromatography , biology , biochemistry , mathematics , geology , operations research , genetics , geotechnical engineering
Summary.— The penetration of fluocinonide from solution in DMSO across human abdominal skin in vitro has been examined. Different volumes of solution, ranging from 0.025 ml to 0.75 ml, were studied. The results show that better penetration is achieved in this in vitro situation from smaller volumes than from larger volumes. Possible mechanisms that might account for this phenomenon are discussed. A possible explanation considers that the flux of water into the DMSO solution causes an increase in the thermodynamic activity of the drug and hence in the penetration rate of the drug into and through the skin.