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JUVENILE DERMATITIS HERPETIFORMIS IN THE LIGHT OF IMMUNOFLUORESCENCE STUDIES
Author(s) -
JABLONSKA S.,
CHORZELSKI T.,
BEUTNER E. H.,
BLASZCZYK M.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb14023.x
Subject(s) - dermatitis herpetiformis , bullous pemphigoid , medicine , dermatology , immunofluorescence , antibody , direct fluorescent antibody , in vivo , indirect immunofluorescence , pathology , immunology , biology , disease , microbiology and biotechnology
Summary.— Eight cases of juvenile dermatitis herpetiformis (JDH) were investigated by direct and indirect IF methods with anti‐IgG and anti‐IgA conjugates. In 3 cases the results were completely negative. In 3 cases there were in vivo fixed IgG in the basement membrane, and in 1 case also circulating antibodies as in bullous pemphigoid in adults. In 2 cases there were in vivo bound IgA deposits in the papillae of the apparently unchanged skin surrounding the lesions, as in dermatitis herpetiformis in adults. The results of the IF studies suggest that JDH is not a nosological entity, and that cases occur with the immunological features of either bullous pemphigoid or dermatitis herpetiformis in adults. There remains the group of immunologically negative cases, the nature of which, moreover, requires further investigation.