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THE EFFECTS OF SOME COMPOUNDS ON THE ENDOGENOUS RESPIRATION OF SKIN
Author(s) -
LONG V. J. W.,
YARDLEY H. J.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07204.x
Subject(s) - respiration , menadione , endogeny , dinitrophenol , 2,4 dinitrophenol , biochemistry , chemistry , substrate (aquarium) , cellular respiration , biology , enzyme , botany , ecology
SUMMARY.— The effects of 2‐bromostearic acid, 2: 4‐dinitrophenol and menadione on the respiration of skin slices in the presence or absence of added glucose was measured. All 3 compounds depress endogeneous respiration, whereas in the presence of added substrate, 2‐bromostearic acid has no effect and 2: 4‐dinitrophenol and menadione stimulate respiration. Since cells in the upper part of the epidermis are in a giucose‐free environment, it is suggested that in vitro tests of potentially toxic substances should be performed both in the presence and in the absence of glucose.