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TOXIC EPIDERMAL NECROLYSIS PRODUCED BY AN EXTRACELLULAR PRODUCT OF STAPHYLOCOCCUS AUREUS
Author(s) -
ARBUTHNOTT J. P.,
KENT JANET,
LYELL A.,
GEMMELL C. G.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07200.x
Subject(s) - toxic epidermal necrolysis , thermolabile , staphylococcus aureus , microbiology and biotechnology , dermatology , extracellular , medicine , chemistry , immunology , biology , bacteria , biochemistry , genetics , enzyme
SUMMARY.— A typical phage group 2 staphylococcal isolate from a case of toxic epidermal necrolysis of Ritter's type produces a diffusible macromolecular thermolabile product which rapidly induces epidermal necrolysis in new‐born mice. The susceptibility to this necrolytic factor decreases markedly with age. The factor responsible has been partly purified.