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THE EFFECT OF TRIMETHOPRIM‐ SULPHAMETHOXAZOLE * ON SEBUM EXCRETION RATE AND BIOCHEMISTRY IN ACNE VULGARIS
Author(s) -
COTTERILL J. A.,
CUNLIFFE W. J.,
WILLIAMSON B.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07197.x
Subject(s) - acne , squalene , excretion , trimethoprim , chemistry , medicine , food science , triglyceride , endocrinology , biochemistry , dermatology , cholesterol , antibiotics
SUMMARY.— The sebum excretion rate and skin surface liquid composition were determined before and after 1 and 2 months of therapy in patients taking a trimethoprim‐sulphamethoxazole combination for acne vulgaris. Trimethoprim‐sulphamethoxazole caused a significant reduction in skin surface free fatty acid and a significant rise in skin surface triglyceride after 1 and 2 mionths of therapy. There were no significant changes in sebum excretion rate, squalene or wax ester.