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HYDROXYUREA IN THE TREATMENT OF PUSTULAR PSORIASIS
Author(s) -
STEIN KENNETH M.,
SHELLEY WALTER B.,
WEINBERG RICHARD A.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07185.x
Subject(s) - psoriasis , pustular psoriasis , medicine , generalized pustular psoriasis , dermatology , hydroxycarbamide , disease
SUMMARY.— Four patients with generalized pustular psoriasis of von Zumbusch were treated with hydroxyurea in an oral dosage of 1–2 g daily. In each instance the pustular, the febrile, the leucocytic and toxic responses were significantly suppressed. It is suggested that the effectiveness of this new treatment reflects the known selective suppressant effect of hydroxyurea on the polymorphonuclear leucocytes, which apparently play a central role in this disease.