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PERCUTANEOUS ABSORPTION OF 1‐NAPHTHOL‐( 14 C) IN MAN
Author(s) -
HARKNESS R. A.,
BEVERIDGE G. W.,
DAVIDSON D. W.
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07174.x
Subject(s) - absorption (acoustics) , urine , 1 naphthol , glucuronic acid , chemistry , toxicity , chromatography , percutaneous , medicine , pharmacology , biochemistry , organic chemistry , materials science , composite material , polysaccharide
SUMMARY.— The percutaneous absorption of 1‐naphthol‐[1‐ 14 C] has been studied in 3 men. This compound was rapidly metabolized and excreted in the urine largely as 1‐naphthol conjugated with glucuronic acid; small quantities of radioactivity were present in the sulphate fraction. The results suggest that absorption was efficient; 65.0–23.8% of the applied dose could not be recovered from the skin. Large systemic doses could thus be administered through the skin. The relevance of the findings to an understanding of toxicity due to these compounds is discussed.