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CYTOTOXIC FACTORS IN INHIBITION OF LYMPHOCYTE TRANSFORMATION IN LYMPHOMATA
Author(s) -
LANGNER ANDRZEJ,
PAWIŃSKAPRONIEWSKA MARIA,
GLIŃSKI WIESLAW,
MAJ STANISLAW
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07170.x
Subject(s) - phytohaemagglutinin , mycosis fungoides , medicine , immunology , lymphocyte , transformation (genetics) , disease , malignant transformation , cytotoxic t cell , cancer research , lymphoma , biology , genetics , in vitro , gene
SUMMARY.— The aim of this study was to investigate the mechanism of inhibition of blastic transformation of phytohaemagglutinin‐stimulated lymphocytes in malignant lymphoreticular proliferations. Thirty‐five untreated cases were examined: 6 reticulosarcoma (RSA), 3 lymphosarcoma (LSA), 7 chronic lymphatic leukaemia (CLL), 8 Hodgkin's disease (HD) and 11 mycosis fungoides (MF). It was demonstrated that the inhibition of transformation of PHA‐stimulated lymphocytes in the groups RSA, LSA and Hodgkin's disease depends in a high degree on factors present in the blood plasma of the patients, whereas in the CLL group it is related to lymphocytes, and is not unblocked by using plasma of healthy individuals. In the MF group the decrease in transformation is relatively small and is more pronounced only in patients with extensive lesions in poor general condition.