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THE MECHANISM OF DELAYED HYPERSENSITIVITY DERANGEMENTS IN RETICULUM CELL LYMPHOMATA (RETICULOSARCOMATA)
Author(s) -
LANGNER ANDRZEJ,
PAWIŃSKAPRONIEWSKA MARIA,
CLIŃSKI WIESLAW
Publication year - 1971
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1971.tb07169.x
Subject(s) - phytohaemagglutinin , cytotoxic t cell , immunology , medicine , antigen , chemistry , immune system , in vitro , biochemistry
SUMMARY.— The authors investigated derangements in delayed hypersensitivity in 2 cases of reticulum cell lymphoma (reticulosarcoma). A cytotoxic factor in the blood plasma of the patients destroyed lymphocytes cultured with phytohaemagglutinin (PHA). The factor proved to be cytotoxic both to the lymphocytes of patients and to those of healthy individuals. The plasma factor, when added in small amounts to the culture medium, stimulated lymphocytes of healthy individuals to blastic transformation; but, at higher concentration, its cytotoxic effect became manifest. A relation was found between the presence of the cytotoxic factor and the clinical state and delayed skin reactions to bacterial and fungal antigens and to allograft rejection.