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FIBRINOLYTIC ACTIVITY IN LESIONS PRODUCED BY MONOCHROMATOR ULTRAVIOLET IRRADIATION IN VARIOUS PHOTODERMATOSES
Author(s) -
GRICE KATHERINE,
RYAN T. J.,
MAGNUS I. A.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb15758.x
Subject(s) - fibrinolysis , medicine , dermatology , sunburn , photodermatosis , pathology , chemistry , xeroderma pigmentosum , dna , biochemistry , dna damage
SUMMARY.– Histological and fibrinolytic activity (FA) changes were studied in skin exposed to visible light and u.v. radiation from a monochromator. There was a marked difference in the early and late lesions produced by irradiation. Late lesions showed loss of fibrinolysis and early lesions showed little or no such change. Absence of fibrinolysis was found in upper dermal vessels in the more delayed sunburn papule reaction and in the delayed reaction in polymorphic light eruption (PLE) and actinic reticuloid, with heavy mononuclear infiltrates appearing as early as I hr. after irradiation. The lesions of PLE and “actinic reticuloid” showed absence of FA. There was no loss of fibrinolysis in the urticarial lesions of solar urticaria (as long as 5 hr. after irradiation) and in the porphyric skin reaction, or in light exposed porphyric skin. These results suggest that impairment of fibrinolysis may play an important part in the delayed reaction to sunburn in the normal, in PLE, actinic reticuloid and photosensitivity with tetrachlorsalicylanilide. By contrast, impairment of fibrinolysis is not a feature of idiopathic solar urticaria or of the more or less acute porphyric photosensitive skin reaction.