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ULTRASTRUCTURAL CHANGES IN HUMAN SKIN MAINTAINED IN ORGAN CULTURE
Author(s) -
SARKANY I.,
GAYLARDE P. M.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb15744.x
Subject(s) - gray (unit) , medicine , organ culture , dermatology , history , biology , biochemistry , in vitro , radiology
SUMMARY Adult human skin maintained in organ culture for up to 3 days was studied electron microscopically to determine the earliest changes in structure. An alteration of the normal keratinization process and migration of epidermal cells were observed during the first 48 hr. At 72 hr. no membraneoating granules and no keratohyalin were present. The basal cells remained essentially normal throughout this period. A new basal lamina appeared under the migrating epidermal cells.