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PLASMA CONCENTRATIONS OF GRISEOFULVIN IN HUMAN VOLUNTEERS
Author(s) -
PLATT D. S.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb15721.x
Subject(s) - griseofulvin , medicine , library science , history , family medicine , dermatology , computer science
SUMMARY Plasma concentrations of griseofulvin have been measured in 10 healthy volunteers to compare the effects of substituting a single daily dose of 500 mg. for a divided dose regimen of 125 mg. 4 times daily. After 14 days treatment no significant difference was observed in the plasma levels from either dose routine. It is concluded, therefore, that medication with griseofulvin can be simplified to single daily doses of 500 mg. and that there should be no loss of efficacy as a result.