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THE IN VITRO METABOLISM OF 7α‐ 3 H DEHYDROEPIANDRO‐STERONE BY HUMAN SKIN
Author(s) -
CHAKRABORTY J.,
THOMSON J.,
MacSWEEN M.P.,
MUIR A.V.,
CALMAN K.C.,
GRANT J.K.,
MILNE J.A.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb15080.x
Subject(s) - dehydroepiandrosterone , androstenediol , in vitro , metabolism , testosterone (patch) , human skin , endocrinology , medicine , axilla , thigh , chemistry , biology , biochemistry , androgen , anatomy , hormone , genetics , cancer , breast cancer
SUMMARY.— Slices of skin from human subjects have been shown to transform 3 H‐dehydroepiandrosterone predominantly to 4‐androstene‐3,17‐dione and 5‐androstene‐3β,17β‐diol. Testosterone, testosterone sulphate and dehydro‐epiandrosterone sulphate were not formed in detectable amounts under the conditions of the investigation. Skin from the shoulder appeared significantly more active than that from the thigh or axilla in metabolizing the dehydro‐epiandrosterone.