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IMMUNO‐HISTOPATHOLOGY OF THE SKIN IN PEMPHIGOID
Author(s) -
CORMANE R. H.,
SZABÒ E.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb15076.x
Subject(s) - staining , bullous pemphigoid , basement membrane , pemphigoid , dermatitis herpetiformis , direct fluorescent antibody , pathology , dermis , antibody , histopathology , chemistry , dermatology , medicine , immunology , disease
SUMMARY.— The in vivo direct immunofluorescent (DIF) staining patterns of the skin surrounding the lesions of 5 patients suffering from pemphigoid are reported. It appeared that fine granular IgG deposits occur in the dermis and more closely packed in the junctional zone of most of the biopsies examined. Only 1 case with a very high (anti‐basement membrane) IgG antibody titre showed a conspicuous linear fluorescence of the basement membrane zone, while 2 other cases with a less high antibody litre showed both types of staining patterns. The impression was gained that there is some relation between the antibody litre and the DIF staining pattern in DH. The findings of this study are also in favour of the concept that pemphigoid and dermatitis herpetiformis are 2 different disease entities; however the existence of intermediate cases cannot be ruled out. The advantages of the DIF method are discussed. An improved filter combination for blue narrow‐band excitation and a rigid control of the conjugates used for IF studies are recommended.