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THE ACTION OF LOCALLY APPLIED BARBITURATES ON SKIN OXYGEN TENSION AND RATE OF OXYGEN UTILIZATION
Author(s) -
NAYLOR P. F. D.,
EVANS N. T. S.
Publication year - 1970
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1970.tb06101.x
Subject(s) - oxygen tension , medicine , action (physics) , unit (ring theory) , family medicine , oxygen , psychology , chemistry , physics , mathematics education , organic chemistry , quantum mechanics
SUMMARY.— Barbiturate solutions were applied to skin after removal of the stratum corneum with Sellotape, and skin surface oxygen tension was measured polarographically. These produced a rise in surface oxygen tension of 30–50 mm. Hg. The rate at which surface oxygen tension fell following arterial occlusion gave a measure of the rate of skin oxygen utilization. This was reduced by a factor which could be as large as 8 after application of barbiturate solutions. It is shown that both epidermal and dermal oxygen utilization rates are reduced, and their return to normal depends on skin blood flow.