Premium
EPIDERMAL CELL REPLACEMENT: TOPOGRAPHICAL VARIATIONS IN ALBINO GUINEA‐PIG SKIN
Author(s) -
CHRISTOPHERS E.,
PETZOLD V.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb16042.x
Subject(s) - epidermis (zoology) , guinea pig , thymidine , cell , population , mitosis , biology , anatomy , dna synthesis , microbiology and biotechnology , dna , pathology , endocrinology , medicine , genetics , environmental health
SUMMARY.— The thickness of ear epidermis in normal albino guinea‐pigs is 60% higher than that of back epidermis. The proliferative activity measured by DNA‐synthesizing cells is equal in both body regions. Cytokinetic analysis of the upward movement of 3 H‐Thymidine‐labelled cells revealed a transit time of about 8 days on the back and about 14 days on the ear. It is concluded that cell differentiation proceeds much more slowly in ear epidermis thus bringing about the increase in the cell population. No difference was found between systemic and intradermal injection of 3 H‐Thymidine.