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AUTDERYTHROCYTE SEXSITIZATION SYNDROME (PAINFUL BRUISING SYNDROME)
Author(s) -
HERSLE K.,
MOBACKEN H.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb16040.x
Subject(s) - medicine , lesion , dermatology , ecchymosis , vasculitis , abdominal pain , pathogenesis , disease , pathology , surgery
SUMMARY.— Autoerythrocyte sensitization syndrome (painful bruising syndrome) is a chronic purpuric cutaneous disease of women, characterized by localized painful inflammatory swellings which in a few hr. develop into painful ecchymoses. Some patients also have systemic manifestations: psychiatric and neurological symptoms, abdominal pain, and genito‐urinary and gastrointestinal bleeding, in that order of prevalence. Histological examination shows an intense vasculitis. Ecchymoses can occur spontaneously, particularly with emotional stress and after mild trauma. The haematological and blood clotting pictures are normal. Intradermal injection of erythrocytes or red cell stroma reproduces the spontaneous lesion. Two patients with this syndrome are presented. In both, typical ecchymotic reactions were induced by the injection of erythrocytes, in one a similar response could be provoked with phosphatidyl L‐serine. The literature is reviewed in detail and the possible pathogenesis of the syndrome is discussed.