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A REVIEW OF PHOTO‐REACTIONS TO HALOGENATED SALICYLANILIDES
Author(s) -
CROW K. D.,
WILKINSON D. S.,
OSMUNDSEN P. E.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb16003.x
Subject(s) - medicine , chemistry , dermatology
SUMMARY.— A review was undertaken of 22 patients originally sensitized by tetrachlorosalicyianilide (T 4 CS) in 1960–61 to determine the pattern of cross‐reactions to tribromosalicylanilide, bithionol and hexachlorophane. Two sets of patch tests were applied, one covered for 48 hr. with black paper, the other irradiated after 24 hr. by a source of “black light”. Readings were taken at 48 and 96 hr. Thirteen of 15 patients re‐tested have remained sensitive to T 4 CS. Fifteen of 22 patients tested gave positive photopatch tests to an “impure” form of T 3 BS, 11 to a laboratory purified form. Half the patients showed positive 48 hr. conventional tests. These were thought likely to be “masked” photo‐reactions. There were 9 positive photo‐reactions to bithionol, but only 1 “conventional” positive reaction. Hexachlorophane only gave 2 positive photo‐reactions. This low incidence is in line with the findings of other investigations. A group of 6 control patients without photodermatitis gave negative reactions to all agents used for testing. “Black light” provides a useful addition to methods of testing for contact photo‐sensitizers.