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PERCUTANEOUS ABSORPTION OF SODIUM FUSIDATE AND FUSIDIC ACID *
Author(s) -
VICKERS C. F. H.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb15972.x
Subject(s) - fusidic acid , antibiotics , penetration (warfare) , sodium , in vitro , absorption (acoustics) , medicine , chemistry , pharmacology , microbiology and biotechnology , bacteria , biochemistry , staphylococcus aureus , biology , materials science , organic chemistry , composite material , genetics , operations research , engineering
SUMMARY.— Evidence is presented that the antibiotic substances sodium fusidate and fusidic acid are both capable of penetrating intact human skin at a rate similar to that seen with glucocorticoids. This is the first experimental in vitro evidence of the penetration of a topically applied antibiotic: the techniques employed depended on the measurement of C14‐labelled material, and upon microbiological assay.