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A HISTOCHEMICAL STUDY OF EXPERIMENTALLY INDUCED MALIGNANT SKIN TUMOURS
Author(s) -
DIENGDOH J. V.,
CHAYEN J.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb15953.x
Subject(s) - medicine , dermatology , library science , computer science
SUMMARY.— The histochemistry of benzpyrene‐induced malignant skin tumours has been studied. The metabolism of these cells appeared to involve suppression of the succinic dehydrogenase‐cytochrome oxidase system; enhanced activity for enzymes of the pentose cycle and increased reaction for enzymes associated with the glycolytic pathway. The inhibition of the “succinoxidase” system has been discussed in relation to the possibility of deletion of the enzyme system by the carcinogen. This might result in the release of the metabolism of these cells from the normal regulatory control of the cytochrome pathway thus producing an enhancement of the growth potential of these cells.