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A PERNIOTIC SYNDROME WITH MONOCYTOSIS AND NEUTROPENIA—A POSSIBLE ASSOCIATION WITH A PRELEUKAEMIC STATE
Author(s) -
MARKS R.,
LIM C. C.,
BORRIE P. F.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb13991.x
Subject(s) - monocytosis , medicine , neutropenia , dermatology , sarcoidosis , nose , pathology , immunology , bone marrow , surgery , chemotherapy
SUMMARY. Three patients, all elderly men, are described with a perniotic type of skin involvement associated with an unusual blood picture with neutropenia and monocytosis. Haematological studies, including repeated marrow examination, have been suspicious of an underlying monocytic leukaemia in each case but no confirmatory evidence has been found and it is probable that these patients have a pre‐leukaemic state. The pattern of skin involvement has been reminiscent of chilblain lupus erythematosus or sarcoidosis, and has been characterized by symmetrical involvement of the backs of the fingers, the toes, the ears and nose by violaceous plaques. The suggestion is made that these patients are examples of a distinct and previously unrecognized entity. The literature concerning the cutaneous manifestations of monocytic leukaemia is briefly reviewed.