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RADIATION DEPIGMENTATION OF MOUSE HAIR: EFFECTS OF MOUSE STRAIN
Author(s) -
POTTEN CHRISTOPHER S.
Publication year - 1969
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1969.tb13983.x
Subject(s) - depigmentation , dermatology , medicine , history , library science , family medicine , computer science
SUMMARY. The radiation depigmentation response of 7 types of mice with various different coat colour genotypes has been studied by counting the number of follicles without pigmentation. The response appears to vary slightly between genotypes, Strong F (dilute brown chinchilla spotted) being the most sensitive. The sensitivity differences cannot be attributed to differences in the number of precursor cells in zigzag follicles. However, the overall precursor pool may vary due to changes in the relative porportions of the follicle types in different genotypes or strains. These small differences within 1 species are discussed in conjunction with the differences in the threshold doses quoted in the literature for depigmentation in various other species.