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NECROTISING VASCULITIS ASSOCIATED WITH LETHAL RETICULOENDOTHELIAL DISEASES
Author(s) -
SAMS W. MITCHELL,
HARVILLE DONALD D.,
WINKELMANN R. K.
Publication year - 1968
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1968.tb12353.x
Subject(s) - vasculitis , medicine , etiology , lymphoma , dermatology , disease , pathology
SUMMARY. Three cases are reported of necrotising vasculitis occurring with or preceding the onset of a malignant reticular disease. The vasculitis occurred at about the time lymphosarcoma was diagnosed in one patient who had received penicillin. In a second patient the appearance of vasculitis preceded the diagnosis of Hodgkin's granuloma by 2 months. And in a third patient, vasculitis was present about 6 years prior to the development of possible multiple myeloma. These cases emphasize that vasculitis and lymphoma may coexist. The clinician must be alert to the possibility of the development of lymphoma in patients with necrotising vasculitis of chronic course. Treatment with immunosuppressive drugs in two patients resulted in only temporary improvement, and the skin lesions recurred in spite of continued therapy. This raises some doubt concerning the immunological etiology of necrotising vasculitis.